Pritam moved to Mumbai to pursue a career in Bollywood. During his stay in Mumbai, he began composing ad jingles and became friendly with a number of other young men struggling to make it big like Shantanu Moitra, Rajkumar Hirani, Sanjay Gadhvi and Jeet Ganguly, who played the guitar with Anup Jalota.
Pritam got his first break when Sanjay Gadhvi was signed on to direct Tere Liye and he in turn signed on his friends Jeet and Pritam as music composers. Though the music was well received, the film sank at the box office.
In 2002 Yashraj Films signed Sanjay Gadhvi up to direct Mere Yaar Ki Shaadi Hai for which the Pritam-Jeet duo once again composed the music. All the songs from that movie were chartbusters and the duo had hit the big time.
His music comprises various kinds including Indian classical music and western influences. Pritam was then actively involved in mentoring and judging new talent on Zee TV's singing competition show Sa Re Ga Ma Pa Challenge 2009.
Pritam followed up the success of Dhoom with a string of successful numbers after a year for Chocolate, Garam Masala and Gangster. Also he composed the music for Dhoom 2, the sequel to Dhoom and Life In A... Metro. He composed the music for Singh Is Kinng and Kismat Konnection and formed a band named Metro.