Reddy first appeared in ghazal singer Pankaj Udhas's "Aur Aahista" music video when she was a graduate.
She caught the attention of Bollywood and was cast in a pivotal role in the 2002 Hindi film Maine Dil Tujhko Diya. In 2004, she appeared in Musafir.
Reddy appeared in the Tamil film Vaaranam Aayiram directed by Gautham Menon, opposite Surya Sivakumar, which was a blockbuster. Reddy's acting and modest portrayal of a confident and down-to-earth girl earned her rave reviews.
Her very first venture into Bollywood was opposite Sohail Khan in Maine Dil Tujko Diya (2002). Even though the film did not do too well, it brought recognition to the actress.Sameera Reddy also did couple of films down south, one of them with Telugu superstar Chiranjeevi.
Both were huge hits. She also did a Bengali film Kalpurush with renowned director Buddhadev Dasgupta. Kalpurush is perhaps her best work so far and her performance bowled over even her worst critics.
Sameera Reddy’s sisters are Sushma and Meghna Reddy. She graduated from Sydenham College.