Sana Khan, whose father is a Tamil-Muslim from Kannur and mother Saeda is from Mumbai, worked as model at her birth place Mumbai, appearing in more than 30 ad films alongside the likes of Shahrukh Khan and Akshay Kumar. She later on, appeared in item numbers in films such as E, Bombay to Goa and Dhan Dhana Dhan Goal, before she was signed in 2008 do to the lead female role in the Tamil film Silambattam opposite Silambarasan, who approached and offered her the role. Playing a talkative, tomboyish brahmin village girl in the film, she won rave reviews for her performance as Jaanu and the ITFA Best New Actress Award in Singapore. Subsequently, she has been signed to do two more Tamil films, Thambikku Indha Ooru with Bharath, Aayiram Vilakku with Shanthnoo Bhagyarajand "Payanam" with Prakash Raj, Nagarjuna, Rishi and others. She is a housemate on Bigg Boss Season 6
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