Charlie Harper (Sheen) is a well-to-do bachelor with a house at the beach, a Jaguar in the garage and an easy way with women. But interrupting his casual Malibu lifestyle is his brother, Alan (Cryer), and Alan's young son, Jake. Complicating matters further are Charlie and Alan's narcissistic mother, Evelyn, Alan's deeply neurotic ex-wife, Judith, Charlie's domineering...

Charlie Harper (Sheen) is a well-to-do bachelor with a house at the beach, a Jaguar in the garage and an easy way with women. But interrupting his casual Malibu lifestyle is his brother, Alan (Cryer), and Alan's young son, Jake. Complicating matters further are Charlie and Alan's narcissistic mother, Evelyn, Alan's deeply neurotic ex-wife, Judith, Charlie's domineering housekeeper, Berta, and Rose, a crazy neighbor who had a brief fling with Charlie. This season, look out for guest appearances from Missi Pyle (Brining Down The House), Jeri Ryan (Boston Public), Camryn Mahein (Ghost Whisperer), Denise Richards (Starship Troopers) and Paget Brewster (Criminal Minds).