Model, actress, costume designer, director and producer Renu Desai made her maiden foray into cinema with the 2000 movie Badri, opposite Pawan Kalyan. She then starred in the Tamil movie James Pandu. Her last Telugu movie and also last movie as an actress was the 2003 movie Johnny. This movie was written and directed by Pawan Kalyan, who also starred in this project. Pawan Kalyan and Renu Desai got married in 2009 and have two children together. The couple went through a divorce and split up in 2012.
Now, we hear that Renu Desai is making a comeback to Telugu films with 2 new projects. She will be first working alongside Bellamkonda Sai in the biopic of dreaded bandit Tiger Nageswara Rao. A little birdie close to the unit reveals, "Renu Desai will be playing the role of famous writer and activist Hemalatha Lavanam, who fought for many social causes including the oppression of untouchability." Renu has stated that she will reveal the details of her second project shortly.
After her divorce, Renu Desai moved back to Marathi films where she worked as a costume designer for five movies and also worked as an editor for a couple of songs. Renu made her directorial debut in the 2014 movie Ishq Wala Love. She debuted as a producer with the Marathi movie Mangalashtak Once More, under her Shree Aadhya Films banner in 2013.